RPS6KA3 / RSK2

ribosomal protein S6 kinase, 90kDa, polypeptide 3

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3. Phosphorylates DAPK1.

☰ Filters

Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

RPS6KA3 / RSK2 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (1)

Select

Human RPS6KA3 / RSK2 Protein (Recombinant GST, N-terminus) (aa631-740) - LS-G59978

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

Select

Human RPS6KA3 / RSK2 Protein (Recombinant GST, N-terminus) (aa2-95) - LS-G59979

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

RPS6KA3 / RSK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116546

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.6 kDa

Price:

100 µg/$710

Select

Human RPS6KA3 / RSK2 Protein (Recombinant GST) (Full Length) - LS-G30259

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

110.2 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human RPS6KA3 / RSK2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66895

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.6 kDa

Price:

20 µg/$1,107

Select

Human RPS6KA3 / RSK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78670

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.6 kDa

Price:

20 µg/$215

Viewing 1-6 of 6 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.