RPS3 / Ribosomal Protein S3

ribosomal protein S3

Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

RPS3 / Ribosomal Protein S3 (7)

Publications

No (7)

Tag

6His, N-terminus (1)

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Fruit fly (1)

Human (5)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

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RPS3 / Ribosomal Protein S3 (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122430

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.5 kDa

Price:

100 µg/$494

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Human RPS3 / Ribosomal Protein S3 (Recombinant 6His-SUMO, N-terminus) (Full Length) - LS-G136409

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Molecular Weight:

42.6 kDa

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Fruit fly RPS3 / Ribosomal Protein S3 (Recombinant 6His, N-terminus) (Full Length) - LS-G137106

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

31.5 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human RPS3 / Ribosomal Protein S3 (Recombinant GST, N-terminus) (aa144-243) - LS-G59974

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RPS3 / Ribosomal Protein S3 (Recombinant GST) (Full Length) - LS-G30251

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

52.47 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RPS3 / Ribosomal Protein S3 (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74082

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.5 kDa

Price:

20 µg/$150

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Human RPS3 / Ribosomal Protein S3 (Recombinant His) - LS-G1473

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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