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RPL13A
Ribosomal protein L13a
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
| Gene Name: | Ribosomal protein L13a |
| Synonyms: | RPL13A, 60S ribosomal protein L13a, 23 kDa highly basic protein, L13A, Ribosomal protein L13a, TSTA1 |
| Target Sequences: | NM_012423 NP_036555.1 P40429 |
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