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RNF19A / DORFIN
ring finger protein 19A, RBR E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
| Gene Name: | ring finger protein 19A, RBR E3 ubiquitin protein ligase |
| Synonyms: | RNF19A, DORFIN, Double ring-finger protein, RING finger protein 19 isoform, RNF19, Ring finger protein 19, p38, p38 protein, RING finger protein 19A |
| Target Sequences: | NM_015435 NP_056250.3 Q9NV58 |
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