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E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Gene Name: | membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase |
Synonyms: | MARCH4, RING finger protein 174, KIAA1399, MARCH-IV, RNF174 |
Target Sequences: | NP_065865.1 Q9P2E8 |
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