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Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production.
Gene Name: | ring finger protein 135 |
Synonyms: | RNF135, L13, REUL, RIG-I E3 ubiquitin ligase, Ring finger protein 135, MMFD, Riplet |
Target Sequences: | NM_032322 NP_115698.3 Q8IUD6 |
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