RNF128 / GRAIL

ring finger protein 128, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.

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Proteins (2)

Type

Recombinant (2)

Target

RNF128 / GRAIL (2)

Publications

No (2)

Tag

GST (1)

GST, N-terminus (1)

Species

Human (2)

Source

Wheat Germ Extract (2)

Purification

Purified (1)

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Human RNF128 / GRAIL Protein (Recombinant GST) (Full Length) - LS-G35204

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

72.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RNF128 / GRAIL Protein (Recombinant GST, N-terminus) (aa329-428) - LS-G63176

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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