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RIPK3 / RIP3
receptor-interacting serine-threonine kinase 3
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
| Gene Name: | receptor-interacting serine-threonine kinase 3 |
| Family/Subfamily: | Protein Kinase , RIP |
| Synonyms: | RIPK3, Receptor interacting protein 3, RIP-like protein kinase 3, RIP3, RIP-3, Receptor-interacting protein 3 |
| Target Sequences: | NM_006871 NP_006862.2 Q9Y572 |
Publications (2)
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