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RIP4 / ANKRD3

receptor-interacting serine-threonine kinase 4

ANKRD3 belongs to the RIP subfamily of kinases. ANKRD3 encodes a deduced 784-amino acid protein with a calculated molecular mass of 86 kD. The protein contains 12 subdomains in the N-terminal region that are highly conserved in all protein kinases, 10 ankyrin-like repeats, and a potential nuclear localization signal. ANKRD3 shares 49% sequence similarity with DAP, but lacks the death domain and the calmodulin-binding domain. ANKRD3 interacts with PKC beta and delta and is likely to play a role in development. Two isoforms are produced by alternative splicing.

Gene Name: receptor-interacting serine-threonine kinase 4
Family/Subfamily: Protein Kinase , RIP
Synonyms: RIPK4, ANKK2, Ankyrin repeat domain 3, ANKRD3, DIK, NKRD3, RIP4, PKK, PPS2
Target Sequences: NM_020639 NP_065690.2 P57078

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).