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RIP4 / ANKRD3
receptor-interacting serine-threonine kinase 4
ANKRD3 belongs to the RIP subfamily of kinases. ANKRD3 encodes a deduced 784-amino acid protein with a calculated molecular mass of 86 kD. The protein contains 12 subdomains in the N-terminal region that are highly conserved in all protein kinases, 10 ankyrin-like repeats, and a potential nuclear localization signal. ANKRD3 shares 49% sequence similarity with DAP, but lacks the death domain and the calmodulin-binding domain. ANKRD3 interacts with PKC beta and delta and is likely to play a role in development. Two isoforms are produced by alternative splicing.
| Gene Name: | receptor-interacting serine-threonine kinase 4 |
| Family/Subfamily: | Protein Kinase , RIP |
| Synonyms: | RIPK4, ANKK2, Ankyrin repeat domain 3, ANKRD3, DIK, NKRD3, RIP4, PKK, PPS2 |
| Target Sequences: | NM_020639 NP_065690.2 P57078 |
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