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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RICK / RIP2

receptor-interacting serine-threonine kinase 2

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

Gene Name: receptor-interacting serine-threonine kinase 2
Family/Subfamily: Protein Kinase , RIP
Synonyms: RIPK2, CARD-carrying kinase, CARDIAK, Growth-inhibiting gene 30, Receptor interacting protein 2, Receptor-interacting protein 2, Rick Kinase, RIP2, RICK, RIP-2, Tyrosine-protein kinase RIPK2, CARD3, GIG30
Target Sequences: NM_003821 NP_003812.1 O43353

Filtered by: None
Target
RICK / RIP2 (77)
Reactivity
Human (61)
Mouse (53)
Rat (41)
Bovine (4)
Dog (4)
Guinea pig (4)
Horse (6)
Monkey (2)
Rabbit (6)
Application
IHC (23)
IHC-Fr (2)
IHC-P (9)
WB (76)
ELISA (27)
ICC (4)
IF (7)
IP (2)
Peptide-ELISA (1)
Host
rabbit (72)
mouse (4)
rat (1)
Isotype
IgG (37)
IgG1,k (2)
IgG2a (1)
IgG2a,k (2)
Clonality
monoclonal mc (5)
polyclonal pc (72)
Clone
3D9 (1)
6F7 (1)
7F5 (1)
Format
AP Conjugated (2)
APC (3)
APC Conjugated (4)
Azide-free (1)
Biotin Conjugated (7)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (7)
HRP Conjugated (7)
PE Conjugated (5)
Unconjugated (39)
Epitope
aa1-294 (8)
aa432-540 (8)
aa458-488 (8)
C-Terminus (4)
pSer176 (3)
120-200 aa (2)
N-Terminal (1)
aa1-540 (1)
aa11-30 (1)
aa146-195 (1)
aa39-68 (1)
aa495-514 (1)
Publications
No (77)
Showing 1-25 of 77 results

IHC-plus™ RICK / RIP2 Antibody LS-B1394
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $545.00
Anti-RIPK2 / RIP2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunocytochemistry of RICK in K562 cells with RICK antibody at 5 ug/ml.

RICK / RIP2 Antibody (clone 3D9) LS-C133570
Mouse Monoclonal [clone 3D9] (IgG2a,k) to Human RICK / RIP2
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg  $365.00
RIPK2 monoclonal antibody (M03), clone 3D9 Western blot of RIPK2 expression in HeLa.
RIPK2 monoclonal antibody (M03), clone 3D9. Western blot of RIPK2 expression in PC-12.

RICK / RIP2 Antibody (120-200 aa) LS-C381392
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Phospho-RIP2 (S176) antibody

RICK / RIP2 Antibody (phospho-Ser176) LS-C415781
Rabbit Polyclonal to Human RICK / RIP2
Mouse, Human
WB
Unconjugated
100µg  $305.00
Western blot of 293 cell lysate using Phospho-RIPK2(Ser176) Antibody

RICK / RIP2 Antibody LS-C332122
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
IF, IHC, WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded human liver cancer using RIPK2 antibody at dilution of 1:100 (200x lens).
Immunohistochemistry of paraffin-embedded mouse kidney using RIPK2 antibody at dilution of 1:100 (200x lens).

RICK / RIP2 Antibody (aa458-488) LS-C97216
Rabbit Polyclonal to Human RICK / RIP2
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with RIPK2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

RICK / RIP2 Antibody (clone 6F7) LS-C133569
Mouse Monoclonal [clone 6F7] (IgG2a,k) to Human RICK / RIP2
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µg  $375.00
RIPK2 monoclonal antibody (M02), clone 6F7 Western blot of RIPK2 expression in HeLa.
RIPK2 monoclonal antibody (M02), clone 6F7. Western blot of RIPK2 expression in NIH/3T3.

RICK / RIP2 Antibody (aa146-195) LS-C199543
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using RIPK2 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from rat brain cells, using RIPK2 Antibody. The lane on the right is blocked with the synthesized peptide.

RICK / RIP2 Antibody (120-200 aa) LS-C385930
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of RIP2 antibody

RICK / RIP2 Antibody LS-C62150
Mouse Monoclonal (IgG1,k) to Human RICK / RIP2
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
100µl  $305.00
Western blot Image

IHC-plus™ RICK / RIP2 Antibody (clone 7F5) LS-B10054
Mouse Monoclonal [clone 7F5] (IgG1,k) to Human RICK / RIP2
Human
ELISA, IHC, IHC-Fr, WB
Unconjugated
50µg  $495.00
IHC with RIPK2 antibody on frozen human pancreas.
RIPK2 monoclonal antibody, clone 7F5 Western blot of RIP2 expression in HeLa.

RICK / RIP2 Antibody LS-C296
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Rat, Human
ELISA, ICC, IF, WB
Unconjugated
0.1mg  $365.00
Immunocytochemistry of RICK in A431 cells with RICK antibody at 10 µg/ml.
Immunocytochemistry of RICK in K562 cells with RICK antibody at 2.5 µg/mL.

RICK / RIP2 Antibody (phospho-Ser176) LS-C415782
Rabbit Polyclonal to Human RICK / RIP2
Mouse, Human
WB
Unconjugated
100µg  $305.00

RICK / RIP2 Antibody (phospho-Ser176) LS-C800207
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00

RICK / RIP2 Antibody LS-C804226
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00

RICK / RIP2 Antibody (aa458-488) LS-C328547
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl  $590.00

RICK / RIP2 Antibody (aa458-488, Biotin) LS-C220582
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200µl  $740.00

RICK / RIP2 Antibody (aa458-488, FITC) LS-C220583
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200µl  $740.00

RICK / RIP2 Antibody (aa458-488, APC) LS-C220580
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200µl  $740.00

RICK / RIP2 Antibody (aa458-488, AP) LS-C220581
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
AP Conjugated
200µl  $740.00

RICK / RIP2 Antibody (aa458-488, Azide-free, HRP) LS-C220584
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

RICK / RIP2 Antibody (aa432-540) LS-C374240
Rabbit Polyclonal to Human RICK / RIP2
Mouse, Rat, Human
ICC, IP, WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $295.00; 1ml 0.5mg/ml  $495.00
Western blot of RICK / RIP2 antibody.
Western Blot Sample: Lane1: Mouse Placenta Tissue; Lane2: Rat Placenta Tissue; Lane3: Human K562 Cells.

RICK / RIP2 Antibody LS-C318451
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Human
ELISA, WB
Unconjugated
50µg  $285.00; 100µg  $385.00
IHC image of RIPK2 Antibody diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of RIPK2 Antibody diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

RICK / RIP2 Antibody (aa1-540) LS-C376497
Rabbit Polyclonal (IgG) to Human RICK / RIP2
Human
ELISA, IHC, IHC-P
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human prostate using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human placenta using antibody at 1:100 dilution.

RICK / RIP2 Antibody (aa39-68) LS-C162614
Rabbit Polyclonal to Human RICK / RIP2
Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
RIPK2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human placenta tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
RIPK2 Antibody western blot of Raji cell line lysates (35 ug/lane). The RIPK2 antibody detected the RIPK2 protein (arrow).
Showing 1-25 of 77 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).