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RICK / RIP2

receptor-interacting serine-threonine kinase 2

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

Gene Name: receptor-interacting serine-threonine kinase 2
Family/Subfamily: Protein Kinase , RIP
Synonyms: RIPK2, CARD-carrying kinase, CARDIAK, Growth-inhibiting gene 30, Receptor interacting protein 2, Receptor-interacting protein 2, Rick Kinase, RIP2, RICK, RIP-2, Tyrosine-protein kinase RIPK2, CARD3, GIG30
Target Sequences: NM_003821 NP_003812.1 O43353

☰ Filters
Products
Antibodies (71)
Primary (71)
RICK / RIP2 (71)
Human (55)
Mouse (47)
Rat (39)
Bovine (3)
Dog (3)
Guinea pig (3)
Horse (5)
Monkey (2)
Rabbit (5)
IHC (23)
IHC-Fr (2)
IHC-P (6)
WB (69)
ELISA (23)
ICC (4)
IF (8)
IP (1)
Peptide-ELISA (3)
rabbit (67)
mouse (3)
rat (1)
Product Group
IHCPlus (2)
IgG (34)
IgG1,k (1)
IgG2a (1)
IgG2a,k (2)
monoclonal mc (4)
polyclonal pc (67)
3D9 (1)
6F7 (1)
7F5 (1)
APC (3)
APC Conjugated (4)
Azide-free (1)
Biotin Conjugated (7)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (7)
HRP Conjugated (7)
PE Conjugated (5)
Unconjugated (35)
aa1-294 (8)
aa432-540 (8)
aa458-488 (7)
C-Terminus (4)
120-200 aa (2)
pSer176 (2)
N-Terminal (1)
Ser176 (1)
aa1-540 (1)
aa11-30 (1)
aa146-195 (1)
aa39-68 (1)
aa495-514 (1)
p176 (1)
No (71)
RICK / RIP2 Antibody - Anti-RIPK2 / RIP2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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RICK / RIP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$440
RICK / RIP2 Antibody - RIPK2 monoclonal antibody (M03), clone 3D9 Western blot of RIPK2 expression in HeLa.
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RICK / RIP2 Mouse anti-Human Monoclonal (3D9) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$423
RICK / RIP2 Antibody - Western blot of Phospho-RIP2 (S176) antibody
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RICK / RIP2 Rabbit anti-Human Polyclonal (120-200 aa) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
RICK / RIP2 Antibody - RIPK2 monoclonal antibody (M02), clone 6F7 Western blot of RIPK2 expression in HeLa.
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RICK / RIP2 Mouse anti-Human Monoclonal (6F7) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
RICK / RIP2 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using RIPK2 antibody at dilution of 1:100 (200x lens).
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RICK / RIP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
RICK / RIP2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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RICK / RIP2 Rabbit anti-Human Polyclonal (aa458-488) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
RICK / RIP2 Antibody - 1:200 staining human lymph node tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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RICK / RIP2 Rabbit anti-Human Polyclonal (pSer176) Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
RICK / RIP2 Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using RIPK2 Antibody. The picture on the right is blocked with the synthesized peptide.
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RICK / RIP2 Rabbit anti-Human Polyclonal (aa146-195) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
RICK / RIP2 Antibody - Western blot of RIP2 antibody
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RICK / RIP2 Rabbit anti-Human Polyclonal (120-200 aa) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
RICK / RIP2 Antibody - IHC with RIPK2 antibody on frozen human pancreas.
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RICK / RIP2 Mouse anti-Human Monoclonal (7F5) Antibody
Human
ELISA, IHC, IHC-Fr, WB
Unconjugated
50 µg/$460
RICK / RIP2 Antibody - Immunocytochemistry of RICK in A431 cells with RICK antibody at 10 µg/ml.
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RICK / RIP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, WB
Unconjugated
0.1 mg/$460
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RICK / RIP2 Rabbit anti-Human Polyclonal (aa458-488) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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RICK / RIP2 Rabbit anti-Human Polyclonal (aa458-488) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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RICK / RIP2 Rabbit anti-Human Polyclonal (aa458-488) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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RICK / RIP2 Rabbit anti-Human Polyclonal (aa458-488) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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RICK / RIP2 Rabbit anti-Human Polyclonal (aa458-488) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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RICK / RIP2 Rabbit anti-Human Polyclonal (aa458-488) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
RICK / RIP2 Antibody - Western blot of RICK / RIP2 antibody.
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RICK / RIP2 Rabbit anti-Human Polyclonal (aa432-540) Antibody
Mouse, Rat, Human
ICC, IP, WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
RICK / RIP2 Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using RIPK2 (Phospho-Ser176) antibody.
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RICK / RIP2 Rabbit anti-Human Polyclonal (pSer176) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
RICK / RIP2 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using RIPK2 (Ab-176) antibody.
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RICK / RIP2 Rabbit anti-Human Polyclonal (p176) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
RICK / RIP2 Antibody - IHC image of RIPK2 Antibody diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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RICK / RIP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
RICK / RIP2 Antibody - Immunohistochemistry of paraffin-embedded human prostate using antibody at 1:100 dilution.
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RICK / RIP2 Rabbit anti-Human Polyclonal (aa1-540) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
RICK / RIP2 Antibody - Staining 293 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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RICK / RIP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
RICK / RIP2 Antibody - RIPK2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human placenta tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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RICK / RIP2 Rabbit anti-Human Polyclonal (aa39-68) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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RICK / RIP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$338; 100 µl/$431
Viewing 1-25 of 71 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).