RGMA

repulsive guidance molecule family member a

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

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Products

Proteins (15)

Type

Over-Expression Lysate (8)

Recombinant (7)

Target

RGMA (15)

Publications

No (15)

Tag

10His, N-terminus + Myc, C-terminus (1)

6His, N-terminus (2)

GST, N-terminus (1)

His (1)

MBP, N-terminus + 6His, C-terminus (1)

Myc-DDK (Flag) (9)

Species

Human (11)

Source

293T Cells (4)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (5)

Human Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (3)

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Human RGMA Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (Full Length) - LS-G136496

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

35.5 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human RGMA Protein (Recombinant MBP, N-terminus + 6His, C-terminus) (Full Length) - LS-G136883

Source:

Baculovirus

Tag:

MBP, N-terminus + 6His, C-terminus

Molecular Weight:

72.5 kDa

Price:

100 µg/$1,164; 20 µg/$475; 1 mg/$2,187

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RGMA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129853

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.5 kDa

Price:

100 µg/$494

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RGMA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129812

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48 kDa

Price:

100 µg/$494

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RGMA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129814

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48 kDa

Price:

100 µg/$494

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Human RGMA Protein (Recombinant GST, N-terminus) (aa326-423) - LS-G62891

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RGMA Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68720

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.2 kDa

Price:

20 µg/$1,107

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Human RGMA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82917

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.5 kDa

Price:

20 µg/$150

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Human RGMA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82918

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48 kDa

Price:

20 µg/$150

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Human RGMA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82919

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48 kDa

Price:

20 µg/$150

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Human RGMA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82920

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.2 kDa

Price:

20 µg/$215

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Human RGMA Protein (Recombinant His) (Met1-Gly422) - LS-G98650

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

43 kDa

Price:

100 µg/$721

Select

RGMA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101665

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.2 kDa

Price:

100 µg/$710

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Human RGMA Protein (Recombinant 6His, N-terminus) (Pro169-Gly422) - LS-G139197

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

29.8 kDa

Price:

10 µg/$368; 50 µg/$479

Select

Human RGMA Protein (Recombinant 6His, N-terminus) (Pro169-Gly422) - LS-G39817

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

29.8kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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