RFX3

regulatory factor X, 3 (influences HLA class II expression)

Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. Acts as a transcription factor. Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

RFX3 (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human RFX3 Protein (Recombinant GST) (Full Length) - LS-G30157

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

108.13 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RFX3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75540

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.3 kDa

Price:

20 µg/$150

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Human RFX3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65428

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.3 kDa

Price:

20 µg/$1,107

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RFX3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102228

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.3 kDa

Price:

100 µg/$494

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