RFWD3

ring finger and WD repeat domain 3

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.

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Products

Antibodies (9)

Type

Primary (9)

Target

RFWD3 (9)

Reactivity

Human (9)

Application

IHC (2)

IHC-P (1)

WB (7)

ELISA (2)

IF (2)

IP (2)

Peptide-ELISA (3)

Host

rabbit (9)

Isotype

IgG (8)

Clonality

polyclonal pc (9)

Format

Unconjugated (9)

Epitope

Internal (1)

aa175-225 (1)

aa358-407 (1)

aa374-423 (1)

aa724-774 (1)

aa75-125 (1)

Publications

No (9)

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RFWD3 Antibody (Internal) LS-C358279

Antibody:

RFWD3 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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RFWD3 Antibody LS-C754169

Antibody:

RFWD3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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RFWD3 Antibody LS-C805356

Antibody:

RFWD3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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RFWD3 Antibody LS-C824547

Antibody:

RFWD3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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RFWD3 Antibody (aa374-423) LS-C120343

Antibody:

RFWD3 Rabbit anti-Human Polyclonal (aa374-423) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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RFWD3 Antibody (aa358-407) LS-C200591

Antibody:

RFWD3 Rabbit anti-Human Polyclonal (aa358-407) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

RFWD3 Antibody (aa724-774) LS-C288192

Antibody:

RFWD3 Rabbit anti-Human Polyclonal (aa724-774) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

RFWD3 Antibody (aa75-125) LS-C288188

Antibody:

RFWD3 Rabbit anti-Human Polyclonal (aa75-125) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

RFWD3 Antibody (aa175-225) LS-C288190

Antibody:

RFWD3 Rabbit anti-Human Polyclonal (aa175-225) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

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