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RFC4
replication factor C (activator 1) 4, 37kDa
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported.
| Gene Name: | replication factor C (activator 1) 4, 37kDa |
| Synonyms: | RFC4, Activator 1 subunit 4, A1 37 kDa subunit, Activator 1 37 kd subunit, Activator 1 37 kDa subunit, RFC37, Replication factor C subunit 4, RF-C 37 kDa subunit, RFC 37 kDa subunit |
| Target Sequences: | BC024022 NP_002907.1 P35249 |
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