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The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.
Gene Name: | replication factor C (activator 1) 1, 145kDa |
Synonyms: | RFC1, A1 140 kDa subunit, Activator 1 large subunit, Activator 1 140 kDa subunit, Activator 1 subunit 1, DNA-binding protein PO-GA, Replication factor C subunit 1, RF-C 140 kDa subunit, MHC binding factor, beta, PO-GA, MHCBFB, RECC1, Replication factor C1, RFC, RFC140 |
Target Sequences: | NM_002913 NP_002904.3 P35251 |
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