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Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments.
Gene Name: | retinol dehydrogenase 12 (all-trans/9-cis/11-cis) |
Synonyms: | RDH12, LCA13, LCA3, Retinol dehydrogenase 12, SDR7C2 |
Target Sequences: | Q96NR8 Q96NR8 |
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