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RC3H2

ring finger and CCCH-type domains 2

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs By similarity. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs By similarity. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity By similarity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression By similarity. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation.

Gene Name: ring finger and CCCH-type domains 2
Synonyms: RC3H2, MNAB, RING finger protein 164, RNF164
Target Sequences: NM_018835 NP_061323.2 Q9HBD1

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
RC3H2 (3)
No (3)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
RC3H2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
131.5 kDa
100 µg/$710
RC3H2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
131.5 kDa
20 µg/$215
RC3H2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).