RC3H2

ring finger and CCCH-type domains 2

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs By similarity. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs By similarity. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity By similarity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression By similarity. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

RC3H2 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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RC3H2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118917

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

131.5 kDa

Price:

100 µg/$710

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Human RC3H2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91075

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

131.5 kDa

Price:

20 µg/$215

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Human RC3H2 Protein (Recombinant GST, N-terminus) (aa748-847) - LS-G62592

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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