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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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RBM38
RNA binding motif protein 38
RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.
| Gene Name: | RNA binding motif protein 38 |
| Synonyms: | RBM38, CLL-associated antigen KW-5, DJ800J21.2, RNA binding motif protein 38, RNA-binding motif protein 38, RNA-binding protein 38, RNPC1, SEB4D, HSRNASEB, SEB4, SEB4B, SsDNA-binding protein SEB4 |
| Target Sequences: | NM_017495 NP_059965.2 Q9H0Z9 |
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