RBL2 / RB2 p130

retinoblastoma-like 2 (p130)

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

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ELISA Kits (3)

Type

Custom (1)

Sandwich (2)

Target

RBL2 / RB2 p130 (3)

Reactivity

Human (1)

Mouse (1)

Rat (1)

Format

96-Well Strip Plate (3)

Publications

No (3)

Sample Type

Plasma (2)

Serum (2)

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Mouse RBL2 / RB2 p130 (Sandwich ELISA) ELISA Kit - LS-F66517

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Rat RBL2 / RB2 p130 (Custom) ELISA Kit - LS-F65298

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Price:

1 Plate/$783

Select

Human RBL2 / RB2 p130 (Sandwich ELISA) ELISA Kit - LS-F66725

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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