RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.

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Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

RBCK1 (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (5)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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RBCK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109289

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.4 kDa

Price:

100 µg/$494

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RBCK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115290

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.8 kDa

Price:

100 µg/$710

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Human RBCK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71328

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.4 kDa

Price:

20 µg/$1,107

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Human RBCK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89502

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.8 kDa

Price:

20 µg/$215

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Human RBCK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89503

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.4 kDa

Price:

20 µg/$150

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Human RBCK1 Protein (Recombinant GST, N-terminus) (aa3-99) - LS-G61584

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RBCK1 Protein (Recombinant GST) (Full Length) - LS-G32255

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

52.1 kDa

Price:

10 µg/$479; 25 µg/$670

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