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RBBP8 / CTIP

retinoblastoma binding protein 8

Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.

Gene Name: retinoblastoma binding protein 8
Synonyms: RBBP8, CTIP, DNA endonuclease RBBP8, RIM, SAE2, COM1, CtBP-interacting protein, JWDS, RBBP-8, SCKL2, Seckel syndrome 2
Target Sequences: NM_002894 NP_002885.1 Q99708

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Proteins (1)
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RBBP8 / CTIP (1)
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RBBP8 / CTIP Protein - 12.5% SDS-PAGE of human RBBP8 stained with Coomassie Blue
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Wheat Germ Extract
GST
128.3 kDa
2 µg/$439
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).