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RBBP4 / RBAP48

retinoblastoma binding protein 4

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.

Gene Name: retinoblastoma binding protein 4
Synonyms: RBBP4, CAF-I p48, CAF-1 subunit C, CAF-I 48 kDa subunit, MSI1 protein homolog, Histone-binding protein RBBP4, NURF55, RBBP-4, RBAP48
Target Sequences: NM_005610 NP_005601.1 Q09028

Publications (2)

1
Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. Ma P, Lin S, Bartolomei MS, Schultz RM. Biology of reproduction. 2010 83:1027-35. (WB) [PubMed:20720167] [PMC:PMC2994328]
2
Phospho-?Np63a/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas. Ratovitski EA. Cell cycle (Georgetown, Tex.). 2014 13:749-61. (WB; Human) [Full Text Article] [PubMed:24394434] [PMC:PMC3979911] Related Antibodies: LS-C53331.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
RBBP4 / RBAP48 (6)
No (6)
GST (1)
His (1)
His,N-terminus (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Insect Cells (1)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (1)
RBBP4 / RBAP48 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
47.5 kDa
100 µg/$494
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Insect Cells
His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
50 kDa
50 µg/$721; 500 µg/$4,249
RBBP4 / RBAP48 Protein - 12.5% SDS-PAGE of human RBBP4 stained with Coomassie Blue
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Wheat Germ Extract
GST
72.49 kDa
10 µg/$479; 25 µg/$670
RBBP4 / RBAP48 Protein - Purified recombinant protein RBBP4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
47.5 kDa
20 µg/$1,107
RBBP4 / RBAP48 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
47.5 kDa
20 µg/$150
RBBP4 / RBAP48 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).