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RASSF8 encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 |
Synonyms: | RASSF8, C12orf2, HoJ-1, HOJ1 |
Target Sequences: | NM_007211 NP_009142.2 Q8NHQ8 |
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