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RASSF5 / RAPL
Ras association (RalGDS/AF-6) domain family member 5
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
| Gene Name: | Ras association (RalGDS/AF-6) domain family member 5 |
| Synonyms: | RASSF5, New ras effector 1, Novel Ras effector 1, NORE1A, RAPL, Ras effector-like protein, Maxp1, Tumor suppressor RASSF3, NORE1, NORE1B, Rap1-binding protein |
| Target Sequences: | NM_031437 NP_872604.1 Q8WWW0 |
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