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RARA / RAR Alpha

retinoic acid receptor, alpha

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.

Gene Name: retinoic acid receptor, alpha
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: RARA, NR1B1, PML-RAR, RAR-alpha, RARalpha, Retinoic acid receptor alpha, Pml-rara, RAR, RAR alpha, Retinoic acid receptor, alpha
Target Sequences: NM_000964 NP_000955.1 P10276

Publications (1)

1
Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance. Ren M, Pozzi S, Bistulfi G, Somenzi G, Rossetti S, Sacchi N. Molecular and cellular biology. 2005 25:10591-603. [PubMed:16287870] [PMC:PMC1291229]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).