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Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
Gene Name: | Rap guanine nucleotide exchange factor (GEF) 4 |
Synonyms: | RAPGEF4, CGEF2, EPAC2, Nbla00496, CAMP-GEFII, EPAC 2 |
Target Sequences: | NM_007023 NP_008954.2 Q8WZA2 |
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