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RAP1A
RAP1A, member of RAS oncogene family
Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
| Gene Name: | RAP1A, member of RAS oncogene family |
| Family/Subfamily: | Ras GTPase superfamily IPR001806 , RAS oncogene |
| Synonyms: | RAP1A, C21KG, G-22K, GTP-binding protein smg p21A, KREV-1, KREV1, RAP1, RAS-related protein RAP1A, Ras-related protein Rap-1A, Ras-related protein Krev-1, SMGP21 |
| Target Sequences: | NM_002884 NP_002875.1 P62834 |
Publications (1)
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