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RAP1A

RAP1A, member of RAS oncogene family

Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.

Gene Name: RAP1A, member of RAS oncogene family
Family/Subfamily: Ras GTPase superfamily IPR001806 , RAS oncogene
Synonyms: RAP1A, C21KG, G-22K, GTP-binding protein smg p21A, KREV-1, KREV1, RAP1, RAS-related protein RAP1A, Ras-related protein Rap-1A, Ras-related protein Krev-1, SMGP21
Target Sequences: NM_002884 NP_002875.1 P62834

Publications (1)

1
Immunohistochemical assay for detection of K-ras protein expression in metastatic colorectal cancer. Elsabah MT, Adel I. Journal of the Egyptian National Cancer Institute. 2013 25:51-6. (WB; Human) [Full Text Article] [PubMed:23499207]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).