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RANBP3
RAN binding protein 3
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
| Gene Name: | RAN binding protein 3 |
| Synonyms: | RANBP3, RAN-binding protein-3, RAN binding protein 3, Ran-binding protein 3 |
| Target Sequences: | NM_003624 NP_003615.2 Q9H6Z4 |
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