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RAD51L3 / RAD51D

RAD51 paralog D

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.

Gene Name: RAD51 paralog D
Synonyms: RAD51D, BROVCA4, HsTRAD, RAD51 homolog D, RAD51-like protein 3, Recombination repair protein, R51H3, RAD51L3, RAD51 (S. cerevisiae)-like 3, RAD51-like 3 (S. cerevisiae), TRAD
Target Sequences: NM_002878 NP_002869.3 O75771

Publications (6)

1
Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression. Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA, Bristow RG. Cancer research. 2004 64:8526-33. [PubMed:15574758]
2
Repression of mutagenesis by Rad51D-mediated homologous recombination. Hinz JM, Tebbs RS, Wilson PF, Nham PB, Salazar EP, Nagasawa H, Urbin SS, Bedford JS, Thompson LH. Nucleic acids research. 2006 34:1358-68. [PubMed:16522646] [PMC:PMC1390685]
3
Disparate requirements for the Walker A and B ATPase motifs of human RAD51D in homologous recombination. Wiese C, Hinz JM, Tebbs RS, Nham PB, Urbin SS, Collins DW, Thompson LH, Schild D. Nucleic acids research. 2006 34:2833-43. [PubMed:16717288] [PMC:PMC1464408]
4
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. Chattopadhyay R, Das S, Maiti AK, Boldogh I, Xie J, Hazra TK, Kohno K, Mitra S, Bhakat KK. Molecular and cellular biology. 2008 28:7066-80. [PubMed:18809583] [PMC:PMC2593380]
5
Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC. Blood. 2009 113:2290-7. [PubMed:19050310] [PMC:PMC2652372]
6
DNA repair genes implicated in triple negative familial non-BRCA1/2 breast cancer predisposition. Ollier M, Radosevic-Robin N, Kwiatkowski F, Ponelle F, Viala S, Privat M, Uhrhammer N, Bernard-Gallon D, Penault-Llorca F, Bignon YJ, Bidet Y. American journal of cancer research. 2015 5:2113-26. (ICC, IHC; Human) [PubMed:26328243] [PMC:PMC4548324] Related Antibodies: LS-C177138.
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Target
RAD51L3 / RAD51D (24)
Reactivity
Human (24)
Mouse (1)
Rat (1)
Chimpanzee (3)
Gibbon (3)
Hamster (1)
Orangutan (3)
Application
IHC (12)
IHC-P (9)
WB (21)
ELISA (4)
ICC (1)
IF (2)
Peptide-ELISA (2)
Host
rabbit (21)
mouse (2)
goat (1)
Isotype
IgG (6)
IgG1 (1)
IgG1,k (1)
Clonality
monoclonal mc (2)
polyclonal pc (22)
Clone
1C8-3C12 (1)
5B3/6 (1)
Format
Biotin Conjugated (3)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (14)
Epitope
C-Terminus (4)
aa259-308 (4)
aa1-328 (2)
100-180 aa, Internal (1)
Ala152 (1)
Internal (1)
aa131-180 (1)
aa2-15 (1)
Publications
No (23)
Yes (1)
Showing 1-24 of 24 results

RAD51L3 / RAD51D Antibody IHC-plus™ LS-B320
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human
IHC IHC-P WB
Unconjugated
100µl 1.9mg/ml  $425.00
Anti-RAD51L3 / RAD51D antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-RAD51L3 / RAD51D antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAD51L3 / RAD51D Antibody (Biotin) LS-C140846
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human
IHC IHC-P WB
Biotin Conjugated
100µl  $365.00
Anti-RAD51L3 / RAD51D antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RAD51D Antibody - Western blot detection of Rad51D (35 kDa) from Hela S3 cell extract.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-RAD51L3 / RAD51D antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RAD51D Antibody - Western blot detection of Rad51D (35 kDa) from Hela S3 cell extract.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAD51L3 / RAD51D Antibody (DY650) LS-C140847
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human
IHC IHC-P WB
DY650 Conjugated
100µl  $365.00
Anti-RAD51L3 / RAD51D antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RAD51D Antibody - Western blot detection of Rad51D (35 kDa) from Hela S3 cell extract.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-RAD51L3 / RAD51D antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RAD51D Antibody - Western blot detection of Rad51D (35 kDa) from Hela S3 cell extract.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAD51L3 / RAD51D Antibody (DY488) LS-C140848
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human
IHC IHC-P WB
DY488 Conjugated
100µl  $365.00
Anti-RAD51L3 / RAD51D antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RAD51D Antibody - Western blot detection of Rad51D (35 kDa) from Hela S3 cell extract.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-RAD51L3 / RAD51D antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RAD51D Antibody - Western blot detection of Rad51D (35 kDa) from Hela S3 cell extract.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAD51L3 / RAD51D Antibody (DY550) LS-C140850
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human
IHC IHC-P WB
DY550 Conjugated
100µl  $365.00
Anti-RAD51L3 / RAD51D antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RAD51D Antibody - Western blot detection of Rad51D (35 kDa) from Hela S3 cell extract.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-RAD51L3 / RAD51D antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RAD51D Antibody - Western blot detection of Rad51D (35 kDa) from Hela S3 cell extract.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAD51L3 / RAD51D Antibody (Ala152) LS-C177138
Publications (1)
Publications (1)
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human
IHC WB
Unconjugated
100µl  $345.00
Western blot of Rad51D (A152) pAb in extracts from Jurkat cells.
Western blot of Rad51D (A152) pAb in extracts from Jurkat cells.

RAD51L3 / RAD51D Antibody (aa131-180) IHC-plus™ LS-B11381
Rabbit Polyclonal (IgG) to Human RAD51L3 / RAD51D
Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
100µl 1mg/ml  $505.00
Anti-RAD51L3 / RAD51D antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Western blot analysis of lysates from Jurkat cells, using RAD51L3 Antibody. The lane on the right is blocked with the synthesized peptide.
Anti-RAD51L3 / RAD51D antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Western blot analysis of lysates from Jurkat cells, using RAD51L3 Antibody. The lane on the right is blocked with the synthesized peptide.

RAD51L3 / RAD51D Antibody LS-C349219
Rabbit Polyclonal (IgG) to Human RAD51L3 / RAD51D
Mouse, Rat, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunofluorescence analysis of A549 cells.
Immunofluorescence analysis of A549 cells.
Immunofluorescence analysis of A549 cells.
Immunofluorescence analysis of A549 cells.

RAD51L3 / RAD51D Antibody (aa1-328) LS-C376430
Rabbit Polyclonal (IgG) to Human RAD51L3 / RAD51D
Human
ELISA IHC IHC-P WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human prostate cancer using antibody at 1:100 dilution.
Western blot. All lanes: DNA repair protein RAD51 homolog 4 antibody at 8 ug/ml+Jurkat whole cell lysate. Secondary antibody: Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 35 kDa. Observed band size: 35 kDa.
Immunohistochemistry of paraffin-embedded human prostate cancer using antibody at 1:100 dilution.
Western blot. All lanes: DNA repair protein RAD51 homolog 4 antibody at 8 ug/ml+Jurkat whole cell lysate. Secondary antibody: Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 35 kDa. Observed band size: 35 kDa.

RAD51L3 / RAD51D Antibody (clone 5B3/6) LS-C2865
Mouse Monoclonal [clone 5B3/6] (IgG1) to Human RAD51L3 / RAD51D
Human
ICC IF WB
Unconjugated
100µl  $335.00
Rad51D detected in HEK293 lysates using an antibody dilution of 1:1000.
Rad51D detected in HEK293 lysates using a 1:1000 dilution of Rad51D antibody (purified).
Rad51D detected in HEK293 lysates using an antibody dilution of 1:1000.
Rad51D detected in HEK293 lysates using a 1:1000 dilution of Rad51D antibody (purified).

RAD51L3 / RAD51D Antibody (100-180 aa, Internal) LS-C385739
Rabbit Polyclonal (IgG) to Human RAD51L3 / RAD51D
Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00

RAD51L3 / RAD51D Antibody (aa1-328) LS-C376433
Rabbit Polyclonal (IgG) to Human RAD51L3 / RAD51D
Human
ELISA IHC IHC-P
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human prostate cancer using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human prostate cancer using antibody at 1:100 dilution.

RAD51L3 / RAD51D Antibody (Internal) LS-C368490
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human
IHC IHC-P WB
Unconjugated
30µl 1mg/ml  $205.00; 100µl 1mg/ml  $245.00; 200µl 1mg/ml  $305.00
Immunohistochemical analysis of RAD51D staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of RAD51D expression in HepG2 (A); HEK293T (B); HeLa (C) whole cell lysates.
Immunohistochemical analysis of RAD51D staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of RAD51D expression in HepG2 (A); HEK293T (B); HeLa (C) whole cell lysates.

RAD51L3 / RAD51D Antibody (clone 1C8-3C12) LS-C198055
Mouse Monoclonal [clone 1C8-3C12] (IgG1,k) to Human RAD51L3 / RAD51D
Human
ELISA WB
Unconjugated
100µg  $355.00
Detection limit for recombinant GST tagged RAD51L3 is approximately 1 ng/ml as a capture antibody.
Detection limit for recombinant GST tagged RAD51L3 is approximately 1 ng/ml as a capture antibody.

RAD51L3 / RAD51D Antibody (C-Terminus) LS-C145404
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human
WB
Unconjugated
50µg  $365.00
RAD51L3 / RAD51D antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RAD51L3 / RAD51D antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAD51L3 / RAD51D Antibody (C-Terminus, HRP) LS-C468765
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human, Orangutan, Gibbon
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
RAD51L3 / RAD51D antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RAD51L3 / RAD51D antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAD51L3 / RAD51D Antibody (C-Terminus, Biotin) LS-C468763
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human, Orangutan, Gibbon
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
RAD51L3 / RAD51D antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RAD51L3 / RAD51D antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAD51L3 / RAD51D Antibody (C-Terminus, FITC) LS-C468764
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human, Orangutan, Gibbon
WB
FITC Conjugated
100µl 1mg/ml  $385.00
RAD51L3 / RAD51D antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
RAD51L3 / RAD51D antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAD51L3 / RAD51D Antibody (aa259-308) LS-C169711
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human
WB
Unconjugated
50µg  $365.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAD51L3 / RAD51D Antibody (aa259-308, HRP) LS-C468762
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human, Chimpanzee
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAD51L3 / RAD51D Antibody (aa259-308, Biotin) LS-C468760
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human, Chimpanzee
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAD51L3 / RAD51D Antibody (aa259-308, FITC) LS-C468761
Rabbit Polyclonal to Human RAD51L3 / RAD51D
Human, Chimpanzee
WB
FITC Conjugated
100µl 1mg/ml  $385.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAD51L3 / RAD51D Antibody LS-C664331
Rabbit Polyclonal (IgG) to Human RAD51L3 / RAD51D
Human
Unconjugated
100µg  $335.00

RAD51L3 / RAD51D Antibody (aa2-15) LS-C55355
Goat Polyclonal to Human RAD51L3 / RAD51D
Hamster, Human
Peptide-ELISA
Unconjugated
100µg  $335.00
Showing 1-24 of 24 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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