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Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.
RAD51 paralog D
RAD51D, BROVCA4, HsTRAD, RAD51 homolog D, RAD51-like protein 3, Recombination repair protein, R51H3, RAD51L3, RAD51 (S. cerevisiae)-like 3, RAD51-like 3 (S. cerevisiae), TRAD
Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression. Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA, Bristow RG. Cancer research. 2004 64:8526-33.
Disparate requirements for the Walker A and B ATPase motifs of human RAD51D in homologous recombination. Wiese C, Hinz JM, Tebbs RS, Nham PB, Urbin SS, Collins DW, Thompson LH, Schild D. Nucleic acids research. 2006 34:2833-43.
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. Chattopadhyay R, Das S, Maiti AK, Boldogh I, Xie J, Hazra TK, Kohno K, Mitra S, Bhakat KK. Molecular and cellular biology. 2008 28:7066-80.
Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC. Blood. 2009 113:2290-7.
DNA repair genes implicated in triple negative familial non-BRCA1/2 breast cancer predisposition. Ollier M, Radosevic-Robin N, Kwiatkowski F, Ponelle F, Viala S, Privat M, Uhrhammer N, Bernard-Gallon D, Penault-Llorca F, Bignon YJ, Bidet Y. American journal of cancer research. 2015 5:2113-26. (ICC, IHC; Human)
Related Antibodies: LS-C177138.