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Unfortunately, the antibody (ID:10610) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



RAD51C

RAD51 paralog C

Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.

Gene Name: RAD51 paralog C
Synonyms: RAD51C, FANCO, RAD51 homolog C, RAD51-like protein 2, Yeast RAD51 homolog 3, R51H3, BROVCA3, RAD51L2
Target Sequences: NM_002876 NP_002867.1 O43502

Publications (17)

1
Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes. Dosanjh MK, Collins DW, Fan W, Lennon GG, Albala JS, Shen Z, Schild D. Nucleic acids research. 1998 26:1179-84. (Yeast) [PubMed:9469824] [PMC:PMC147393]
2
Complex formation by the human RAD51C and XRCC3 recombination repair proteins. Masson JY, Stasiak AZ, Stasiak A, Benson FE, West SC. Proceedings of the National Academy of Sciences of the United States of America. 2001 98:8440-6. (WB, IP; Human) [PubMed:11459987] [PMC:PMC37455]
3
Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. French CA, Masson JY, Griffin CS, O'Regan P, West SC, Thacker J. The Journal of biological chemistry. 2002 277:19322-30. (ICC, WB, IP; Human) [PubMed:11912211]
4
Autoantibodies in sera of pancreatic cancer patients identify recombination factor Rad51 as a tumour-associated antigen. Maacke H, Hundertmark C, Miska S, Voss M, Kalthoff H, Strzbecher HW. Journal of cancer research and clinical oncology. 2002 128:219-22. (IHC, WB; Human) [PubMed:11935313]
5
Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Godthelp BC, Wiegant WW, van Duijn-Goedhart A, Schrer OD, van Buul PP, Kanaar R, Zdzienicka MZ. Nucleic acids research. 2002 30:2172-82. (ICC, WB) [PubMed:12000837] [PMC:PMC115287]
6
Inactivation of the RAD51 recombination pathway stimulates UV-induced mutagenesis in mammalian cells. Lambert S, Lopez BS. Oncogene. 2002 21:4065-9. [PubMed:12037689]
7
RAD51C is required for Holliday junction processing in mammalian cells. Liu Y, Masson JY, Shah R, O'Regan P, West SC. Science (New York, N.Y.). 2004 303:243-6. (Human) [PubMed:14716019]
8
Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression. Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA, Bristow RG. Cancer research. 2004 64:8526-33. [PubMed:15574758]
9
Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51. Bennett BT, Knight KL. Journal of cellular biochemistry. 2005 96:1095-109. [PubMed:16215984]
10
Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C. Nagaraju G, Odate S, Xie A, Scully R. Molecular and cellular biology. 2006 26:8075-86. [PubMed:16954385] [PMC:PMC1636746]
11
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu Y, Martin BK, Burkett S, Southon E, Pati D, Tessarollo L, West SC, Donovan PJ, Nussenzweig A, Sharan SK. The Journal of cell biology. 2007 176:581-92. [PubMed:17312021] [PMC:PMC2064017]
12
Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, Belmaaza A, Wouters B, Bristow RG. Cancer research. 2008 68:605-14. [PubMed:18199558]
13
Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC. Blood. 2009 113:2290-7. [PubMed:19050310] [PMC:PMC2652372]
14
Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C. Gildemeister OS, Sage JM, Knight KL. The Journal of biological chemistry. 2009 284:31945-52. [PubMed:19783859] [PMC:PMC2797266]
15
Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome. Sage JM, Gildemeister OS, Knight KL. The Journal of biological chemistry. 2010 285:18984-90. [PubMed:20413593] [PMC:PMC2885175]
16
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:11800-5. (WB; Human) [PubMed:22753495] [PMC:PMC3406824]
17
MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition. Wang Y, Huang JW, Calses P, Kemp CJ, Taniguchi T. Cancer research. 2012 72:4037-46. (ICC, WB; Human) [PubMed:22761336] [PMC:PMC3421071]
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rad51c (25)
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monoclonal mc (6)
polyclonal pc (19)
Clone
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Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
DY488 Conjugated (1)
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DY650 Conjugated (1)
FITC Conjugated (1)
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PE Conjugated (1)
Unconjugated (15)
Epitope
aa169-198 (8)
Glu185 (1)
Internal (1)
aa130-210 (1)
aa161-210 (1)
aa177-207 (1)
aa2-14 (1)
aa326-376 (1)
Publications
No (25)
Showing 1-25 out of 25 results
RAD51C Antibody (Internal) LS-C358269
Immunohistochemical analysis of RAD51C staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of RAD51C staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

Rabbit Polyclonal to Human RAD51C
Human, Monkey
ICC IF IHC IHC-P WB
Unconjugated
RAD51C Antibody (clone 3F3-5C6) LS-C198054
Immunofluorescence of monoclonal antibody to RAD51C on HeLa cell. [antibody concentration 10 ug/ml]
RAD51C monoclonal antibody (M01), clone 3F3-5C6 Western Blot analysis of RAD51C expression in HeLa.

Mouse Monoclonal [clone 3F3-5C6] (IgG1,k) to Human RAD51C
Human
ELISA IF RNAi WB
Unconjugated
RAD51C Antibody (aa130-210) LS-C385741
Western blot of Rad51C antibody

Rabbit Polyclonal (IgG) to Human RAD51C
Human, Monkey
ELISA IF IHC WB
Unconjugated
RAD51C Antibody LS-C412631

Rabbit Polyclonal to Human RAD51C
Human
IF IHC WB
Unconjugated
RAD51C Antibody (Glu185) LS-C176982
Western blot of Rad51C (E185) pAb in extracts from COS-7 cells.

Rabbit Polyclonal to Human RAD51C
Human
IF IHC WB
Unconjugated
RAD51C Antibody LS-C346156
Immunohistochemistry of paraffin-embedded human prostate.
Immunohistochemistry of paraffin-embedded human stomach tissue.

Rabbit Polyclonal (IgG) to Human RAD51C
Mouse, Human
IHC WB
Unconjugated
RAD51C Antibody (aa169-198) LS-C324506

Rabbit Polyclonal (IgG) to Human RAD51C
Human
ELISA WB
Unconjugated
RAD51C Antibody (aa169-198, Biotin) LS-C267765

Rabbit Polyclonal (IgG) to Human RAD51C
Human
ELISA WB
Biotin Conjugated
RAD51C Antibody (aa169-198, FITC) LS-C267766

Rabbit Polyclonal (IgG) to Human RAD51C
Human
ELISA WB
FITC Conjugated
RAD51C Antibody (aa169-198, Azide-free, HRP) LS-C267767

Rabbit Polyclonal (IgG) to Human RAD51C
Human
ELISA WB
HRP Conjugated, Azide-free
RAD51C Antibody (aa169-198, PE) LS-C267768

Rabbit Polyclonal (IgG) to Human RAD51C
Human
ELISA WB
PE Conjugated
RAD51C Antibody (aa169-198, AP) LS-C267763

Rabbit Polyclonal (IgG) to Human RAD51C
Human
ELISA WB
AP Conjugated
RAD51C Antibody (aa169-198, APC) LS-C267764

Rabbit Polyclonal (IgG) to Human RAD51C
Human
ELISA WB
APC Conjugated
RAD51C Antibody (aa161-210) LS-C199514
Western blot of extracts from COS7 cells, using RAD51L2 Antibody. The lane on the right was incubated with synthetic peptide.

Rabbit Polyclonal (IgG) to Human RAD51C
Human
Peptide-ELISA WB
Unconjugated
RAD51C Antibody (aa2-14) LS-C34651
RAD51C antibody staining (2 ug/ml) of HeLa lysate (RIPA buffer, 30g total protein per lane). Primary incubated for 12 hour. Detected by Western blot of chemiluminescence.
Staining (2?g/ml) of HeLa lysate (RIPA buffer, 30?g total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.

Goat Polyclonal to Human RAD51C
Human
Peptide-ELISA WB
Unconjugated
RAD51C Antibody (clone 2H11/6) LS-C2863
Rad51C detected in HEK293 lysate using LS-C2863.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Mouse Monoclonal [clone 2H11/6] (IgG1,k) to Human RAD51C
Mouse, Human, Primate
WB
Unconjugated
RAD51C Antibody (clone 2H11/6, Biotin) LS-C140851
Rad51C detected in HEK293 lysate using LS-C2863.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Mouse Monoclonal [clone 2H11/6] (IgG1,k) to Human RAD51C
Mouse, Human
WB
Biotin Conjugated
RAD51C Antibody (clone 2H11/6, DY488) LS-C140853
Rad51C detected in HEK293 lysate using LS-C2863.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Mouse Monoclonal [clone 2H11/6] (IgG1,k) to Human RAD51C
Mouse, Human
WB
DY488 Conjugated
RAD51C Antibody (clone 2H11/6, DY550) LS-C140855
Rad51C detected in HEK293 lysate using LS-C2863.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Mouse Monoclonal [clone 2H11/6] (IgG1,k) to Human RAD51C
Mouse, Human
WB
DY550 Conjugated
RAD51C Antibody (clone 2H11/6, DY650) LS-C140852
Rad51C detected in HEK293 lysate using LS-C2863.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Mouse Monoclonal [clone 2H11/6] (IgG1,k) to Human RAD51C
Mouse, Human
WB
DY650 Conjugated
RAD51C Antibody (aa169-198) LS-C162411
RAD51C Antibody western blot of HepG2 cell line lysates (35 ug/lane). The RAD51C antibody detected the RAD51C protein (arrow).

Rabbit Polyclonal to Human RAD51C
Human
WB
Unconjugated
RAD51C Antibody (aa326-376) LS-C289369
Detection of Human RAD51C by Western Blot. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug) and 293T (T; 50 ug) cells. Antibody: Affinity purified rabbit anti-RAD51C antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Rabbit Polyclonal (IgG) to Human RAD51C
Human
WB
Unconjugated
RAD51C Antibody LS-C490465
Western blot Image

Rabbit Polyclonal (IgG) to Human RAD51C
Human
WB
Unconjugated
RAD51C Antibody (aa177-207) LS-C408004
Rad51C antibody Western blot. All lanes: Anti Rad51C at 0.5 ug/ml. Lane 1: A549 Whole Cell Lysate at 40 ug. Lane 2: COLO320 Whole Cell Lysate at 40 ug. Predicted band size: 42 kD. Observed band size: 42 kD.

Rabbit Polyclonal to Human RAD51C
Human
WB
Unconjugated
RAD51C Antibody LS-C497599
Western blot analysis of extracts of various cell lines.

Rabbit Polyclonal (IgG) to Human RAD51C
Mouse, Rat
WB
Unconjugated

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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