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Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.
Gene Name: | RAB22A, member RAS oncogene family |
Family/Subfamily: | Ras GTPase superfamily IPR001806 , RAS oncogene |
Synonyms: | RAB22A, GTP-binding protein RAB22A, Rab-22, RAB22, Ras-related protein Rab-22A |
Target Sequences: | NM_020673 NP_065724.1 Q9UL26 |
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