RAB10

RAB10, member RAS oncogene family

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

RAB10 (7)

Publications

No (6)

Yes (1)

Tag

6His, N-terminus (1)

6His-SUMO, N-terminus (1)

GST (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (4)

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Human RAB10 Protein (Recombinant His) - LS-G2178

(4.0) Rating

(1) Publication(s)

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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RAB10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112833

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.4 kDa

Price:

100 µg/$494

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Human RAB10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86353

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.4 kDa

Price:

20 µg/$150

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Human RAB10 Protein (Recombinant GST) (Full Length) - LS-G32377

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

48.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse RAB10 Protein (Recombinant 6His-SUMO, N-terminus) (aa1-200) - LS-G56476

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human RAB10 Protein (Recombinant 6His, N-terminus) (aa1-196) - LS-G56479

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human RAB10 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70146

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.4 kDa

Price:

20 µg/$1,107

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