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QPRT is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.
Gene Name: | quinolinate phosphoribosyltransferase |
Synonyms: | QPRT, QPRTase, QAPRTase |
Target Sequences: | NM_014298 NP_055113.2 Q15274 |
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