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QPRT

quinolinate phosphoribosyltransferase

QPRT is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.

Gene Name: quinolinate phosphoribosyltransferase
Synonyms: QPRT, QPRTase, QAPRTase
Target Sequences: NM_014298 NP_055113.2 Q15274

Publications (2)

1
Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease. Jones SP, Franco NF, Varney B, Sundaram G, Brown DA, de Bie J, Lim CK, Guillemin GJ, Brew BJ. PloS one. 2015 10:e0131389. (WB; Human) [Full Text Article] [PubMed:26114426] [PMC:PMC4482723] Related Antibodies: LS-C115527.
2
Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages. Yinghong Zheng, Jiayuan Kou, Pengyu Wang, Ting Ye, Zitong Wang, Ziyu Gao, Lin Cong, Manman Li, Bowen Dong, Wei Yang, Quanfeng Li, Hong Li, Rui Wang, Liming Yang. Aging. 2021 Feb;13:7096-7119. [Full Text Article] [PubMed:33639613] [PMC:PMC7993719]

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QPRT ELISA Kit
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0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$854
QPRT ELISA Kit
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Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
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1 Plate/$579
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).