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PVR / CD155

poliovirus receptor

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.

Gene Name: poliovirus receptor
Synonyms: PVR, CD155, Hpvr, HVED, Nectin-like 5, Nectin-like protein 5, Poliovirus receptors beta, Poliovirus receptor, PVS, Necl-5, CD155 antigen, NECL5, TAGE4
Target Sequences: NM_006505 NP_006496.4 P15151

Publications (4)

1
Melanoma Cells Control Antimelanoma CTL Responses via Interaction between TIGIT and CD155 in the Effector Phase. Inozume T, Yaguchi T, Furuta J, Harada K, Kawakami Y, Shimada S. The Journal of investigative dermatology. 2016 January;136:255-63. [Full Text Article] [PubMed:26763445]
2
Melanoma Cells Control Anti-Melanoma CTL Responses via Interaction between TIGIT and CD155 in the Effector Phase. Inozume T, Yaguchi T, Furuta J, Harada K, Kawakami Y, Shimada S. The Journal of investigative dermatology. 2016 January;136:255-263. [Full Text Article] [PubMed:26458009]
3
Intratumoral Delivery of a PD-1-Blocking scFv Encoded in Oncolytic HSV-1 Promotes Antitumor Immunity and Synergizes with TIGIT Blockade. Chaolong Lin , Wenfeng Ren , Yong Luo, Shaopeng Li, Yating Chang, Lu Li, Dan Xiong, Xiaoxuan Huang, Zilong Xu, Zeng Yu, Yingbin Wang, Jun Zhang, Chenghao Huang, Ningshao Xia. Cancer immunology research. 2020 May;8:632-647. [Full Text Article] [PubMed:32127389] Related Antibodies: LS-B10536.
4
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer. William A Freed-Pastor, Laurens J Lambert, Zackery A Ely, Nimisha B Pattada, Arjun Bhutkar, George Eng, Kim L Mercer, Ana P Garcia, Lin Lin, William M Rideout rd, William L Hwang, Jason M Schenkel, Alex M Jaeger, Roderick T Bronson, Peter M K Westcott, Tyler D Hether, Prajan Divakar, Jason W Reeves, Vikram Deshpande, Toni Delorey, Devan Phillips, Omer H Yilmaz, Aviv Regev, Tyler Jacks. Cancer cell. 2021 October;39:1342-1360.e14. [Full Text Article] [PubMed:34358448] [PMC:PMC8511341] Related Antibodies: LS-C376428.
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Proteins (25)
Over-Expression Lysate (6)
Recombinant (19)
PVR / CD155 (25)
No (25)
10His, N-terminus (1)
6His, C-terminus (3)
6His-SUMO, N-terminus (1)
Fc, C-terminus (3)
GST (1)
GST, N-terminus (1)
His (1)
His,C-terminus (4)
His-T7 (2)
mFc, C-terminus (1)
Myc-DDK (Flag) (7)
Human (16)
Monkey-Rhesus (1)
Mouse (3)
Rat (2)
293T Cells (3)
E. coli (4)
HEK 293 Cells (8)
Human Cells (3)
Mammalian Cells (5)
Wheat Germ Extract (2)
Purified (8)
Low endotoxin level (12)
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.13kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
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HEK 293 Cells
Fc, C-terminus
Less than 0.2 EU/µg protein (determined by LAL method).
85-105 kDa
100 µg/$423; 1 mg/$1,475
PVR / CD155 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.9 kDa
100 µg/$494
PVR / CD155 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
39.1 kDa
100 µg/$494
PVR / CD155 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His, N-terminus
46.7 kDa
100 µg/$1,801; 20 µg/$1,247
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.5 kDa
100 µg/$721; 1 mg/$4,701
Select
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
61.8 kDa
100 µg/$721; 1 mg/$4,701
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
28 kDa
100 µg/$721
PVR / CD155 Protein - 12.5% SDS-PAGE of human PVR stained with Coomassie Blue
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Wheat Germ Extract
GST
71.7 kDa
2 µg/$439
PVR / CD155 Protein - Recombinant  Poliovirus Receptor By SDS-PAGE
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E. coli
His-T7
29.0 kDa
10 µg/$289; 50 µg/$490; 100 µg/$782; 200 µg/$977; 1 mg/$2,114; 500 µg/$1,640; 5 mg/$3,417; 2 mg/$2,304
PVR / CD155 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PVR / CD155 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
PVR / CD155 Protein - Purified recombinant protein PVR was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
39.1 kDa
20 µg/$1,107
PVR / CD155 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
39.9 kDa
20 µg/$150
PVR / CD155 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
39.1 kDa
20 µg/$150
PVR / CD155 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
45.1 kDa
20 µg/$150
PVR / CD155 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
45.1 kDa
100 µg/$494
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
35.8 kDa
100 µg/$843
Select
Mammalian Cells
mFc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
61.7 kDa
10 µg/$266; 50 µg/$361
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.4 kDa
10 µg/$297; 50 µg/$460
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
62.2 kDa
10 µg/$281; 50 µg/$389
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.6 kDa
10 µg/$281; 50 µg/$389
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.13 kDa
10 µg/$376; 50 µg/$526
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.6kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
PVR / CD155 Protein - Recombinant Poliovirus Receptor By SDS-PAGE
Select
E. coli
His-T7
31.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).