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Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.
Gene Name: | pseudouridylate synthase 10 |
Synonyms: | PUS10, CCDC139, DOBI, Pseudouridine synthase 10, Pseudouridylate synthase 10, TRNA pseudouridylate synthase, TRNA-uridine isomerase, TRNA pseudouridine 55 synthase, Psi55 synthase |
Target Sequences: | AA213749 NP_653310.2 Q3MIT2 |
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