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Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA.
Gene Name: | Pseudouridylate synthase 1 |
Synonyms: | PUS1, MLASA1, TRNA uridine isomerase I, Pseudouridylate synthase 1, TRNA-uridine isomerase I |
Target Sequences: | NM_025215 NP_079491.2 Q9Y606 |
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