PUF60

poly-U binding splicing factor 60KDa

DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.

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Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

PUF60 (10)

Publications

No (10)

Tag

GST (2)

GST, N-terminus (1)

Myc-DDK (Flag) (6)

Species

Human (8)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (3)

Purification

Purified (3)

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Human PUF60 Protein (Recombinant) (Asn226-Gln549) - LS-G133657

Source:

E. coli

Tag:

None

Molecular Weight:

64.6kDa

Price:

10 µg/$288; 50 µg/$482; 200 µg/$965; 100 µg/$772; 1 mg/$2,098; 500 µg/$1,627; 5 mg/$3,375; 2 mg/$2,288

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PUF60 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114050

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

100 µg/$494

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PUF60 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107893

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.7 kDa

Price:

100 µg/$710

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Human PUF60 Protein (Recombinant GST) (Full Length) - LS-G32639

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

80.63 kDa

Price:

2 µg/$439

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Human PUF60 Protein (Recombinant GST) (Full Length) - LS-G32640

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

82.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PUF60 Protein (Recombinant GST, N-terminus) (aa114-223) - LS-G61848

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PUF60 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66956

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.7 kDa

Price:

20 µg/$1,107

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Human PUF60 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66957

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

20 µg/$1,107

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Human PUF60 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78811

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

20 µg/$150

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Human PUF60 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78812

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.7 kDa

Price:

20 µg/$215

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