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PTPRN / IA-2

protein tyrosine phosphatase, receptor type, N

PTPRN / IA-2 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.

Gene Name: protein tyrosine phosphatase, receptor type, N
Family/Subfamily: Protein Phosphatase , R8
Synonyms: PTPRN, ICA512, IA2, ICA 512, Islet antigen 2, Islet cell antigen 2, Islet cell autoantigen 3, IA-2, Ia-2 antigen, ICA3, PTP-NP-2, PTP IA-2, R-PTP-N, IA-2/PTP, Islet cell antigen 512
Target Sequences: NM_002846 NP_002837.1 Q16849

Publications (1)

1
Presence of diabetes autoantigens in extracellular vesicles derived from human islets. Hasilo CP, Negi S, Allaeys I, Cloutier N, Rutman AK, Gasparrini M, Bonneil É, Thibault P, Boilard É, Paraskevas S. Scientific reports. 2017 7:5000. (ICC, WB, Flo; Human, Hamster) [Full Text Article] [PubMed:28694505] [PMC:PMC5504025] Related Antibodies: LS-C284886.

☰ Filters
Products
Proteins (16)
Over-Expression Lysate (2)
Recombinant (14)
PTPRN / IA-2 (16)
No (16)
6His, N-terminus (7)
6His-Myc, C-terminus (1)
DDK,C-terminus (2)
GST, N-terminus (1)
His (2)
His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (15)
293T Cells (1)
E. coli (9)
HEK 293 Cells (1)
Sf9 Cells (2)
Wheat Germ Extract (1)
Yeast (2)
Purified (3)
Low endotoxin level (7)
PTPRN / IA-2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His-Myc, C-terminus
60.3 kDa
100 µg/$446; 20 µg/$336; 1 mg/$1,460
PTPRN / IA-2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
44.6 kDa
10 µg/$344; 50 µg/$584
PTPRN / IA-2 Protein
Select
E. coli
His
17.8 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
Select
E. coli
His, N-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
predicted 44.6 kDa, observered 50 kDa
20 µg/$205; 100 µg/$235
PTPRN / IA-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
105.85 kDa
100 µg/$710
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22.9 kDa
10 µg/$344; 50 µg/$584
Select
Sf9 Cells
DDK,C-terminus
103 kDa
20 µg/$677
Select
Sf9 Cells
DDK,C-terminus
57.3 kDa
20 µg/$677
PTPRN / IA-2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PTPRN / IA-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
105.85 kDa
20 µg/$215
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.6 kDa
10 µg/$344; 50 µg/$584
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.6kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
44.6kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22.9kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
PTPRN / IA-2 Protein - Recombinant Protein Tyrosine Phosphatase Receptor Type N By SDS-PAGE
Select
E. coli
His
23.0 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).