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PTPRN / IA-2

protein tyrosine phosphatase, receptor type, N

PTPRN / IA-2 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.

Gene Name: protein tyrosine phosphatase, receptor type, N
Family/Subfamily: Protein Phosphatase , R8
Synonyms: PTPRN, ICA512, IA2, ICA 512, Islet antigen 2, Islet cell antigen 2, Islet cell autoantigen 3, IA-2, Ia-2 antigen, ICA3, PTP-NP-2, PTP IA-2, R-PTP-N, IA-2/PTP, Islet cell antigen 512
Target Sequences: NM_002846 NP_002837.1 Q16849

Publications (1)

1
Presence of diabetes autoantigens in extracellular vesicles derived from human islets. Hasilo CP, Negi S, Allaeys I, Cloutier N, Rutman AK, Gasparrini M, Bonneil É, Thibault P, Boilard É, Paraskevas S. Scientific reports. 2017 7:5000. (ICC, WB, Flo; Human, Hamster) [Full Text Article] [PubMed:28694505] [PMC:PMC5504025] Related Antibodies: LS-C284886.

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PTPRN / IA-2 (6)
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96-Well Strip Plate (5)
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Plasma (5)
Serum (5)
Tissue Homogenates (2)
PTPRN / IA-2 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PTPRN / IA-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
PTPRN / IA-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PTPRN / IA-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PTPRN / IA-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PTPRN / IA-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).