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PTPRJ / CD148

protein tyrosine phosphatase, receptor type, J

Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Gene Name: protein tyrosine phosphatase, receptor type, J
Family/Subfamily: Protein Phosphatase , R3
Synonyms: PTPRJ, CD148, CD148 antigen, DEP-1, HPTPeta, HPTP eta, Ptp-eta, R-PTP-J, R-PTP-ETA, Density-enhanced phosphatase 1, DEP1, SCC1
Target Sequences: NM_002843 NP_002834.3 Q12913

Publications (2)

1
Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148. Whiteford JR, Xian X, Chaussade C, Vanhaesebroeck B, Nourshargh S, Couchman JR. Molecular biology of the cell. 2011 22:3609-24. [PubMed:21813734] [PMC:PMC3183016]
2
CAF-1-induced oligomerization of histones H3/H4 and mutually exclusive interactions with Asf1 guide H3/H4 transitions among histone chaperones and DNA. Liu WH, Roemer SC, Port AM, Churchill ME. Nucleic acids research. 2012 40:11229-39. [PubMed:23034810] [PMC:PMC3526290] Related Antibodies: LS-C166881.

☰ Filters
Antibodies (51)
ELISA Kits (9)
Proteins (7)
Custom (1)
Over-Expression Lysate (2)
Primary (51)
Recombinant (5)
Sandwich (8)
PTPRJ / CD148 (67)
Human (46)
Mouse (18)
Rat (8)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
IHC (10)
IHC-P (5)
WB (39)
Flo (9)
ELISA (16)
ICC (6)
IF (8)
IP (1)
rabbit (40)
mouse (11)
Product Group
IHCPlus (1)
IgG (14)
IgG1 (1)
IgG2a (3)
IgG2a,k (1)
IgG2b (5)
monoclonal mc (11)
polyclonal pc (40)
1D2C11 (1)
255 (3)
6F2E12 (1)
6G11 (1)
MEM-CD148/05 (4)
96-Well Microplate (2)
96-Well Strip Plate (7)
AP Conjugated (1)
APC (3)
APC Conjugated (5)
Azide-free (1)
Biotin Conjugated (5)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (5)
HRP Conjugated (4)
PE Conjugated (6)
Preservative Free (1)
Unconjugated (19)
aa1033-1277 (8)
aa1061-1293 (8)
aa567-842 (8)
aa1-444 (2)
861-910 aa, Internal (1)
No (66)
Yes (1)
Cell Lysates (1)
Plasma (2)
Serum (2)
Tissue Homogenates (2)
GST, N-terminus (1)
His-T7 (3)
Myc-DDK (Flag) (3)
Human (4)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (1)
PTPRJ / CD148 Antibody - His6-DEP-1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human tonsil tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$376
PTPRJ / CD148 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$693
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$642
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$825
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$825
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal (AP) Antibody
Human
ELISA, ICC, IF, IHC, WB
AP Conjugated
200 µl/$825
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal (APC) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$825
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal (Azide-free) (HRP) Antibody
Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$825
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal (PE) Antibody
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$825
PTPRJ / CD148 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC-P, WB
Unconjugated
50 µl/$460
PTPRJ / CD148 Antibody
Select
PTPRJ / CD148 Mouse anti-Human Monoclonal (255) Antibody
Human
Flo, IP
Unconjugated
100 µg/$373
PTPRJ / CD148 Antibody - Detection limit for recombinant GST tagged PTPRJ is approximately 0.03 ng/ml as a capture antibody.
Select
PTPRJ / CD148 Mouse anti-Human Monoclonal (6G11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$413
PTPRJ / CD148 Antibody - Western blot of recombinant PTPRJ / CD148.
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal (aa1061-1293) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$294; 200 µl/$334; 500 µl/$467; 1 ml/$533
PTPRJ / CD148 Antibody - Immunohistochemistry of CD148 antibody
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal (861-910 aa, Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
PTPRJ / CD148 Antibody - Western blot analysis using CD148 mAb against HEK293 (1) and CD148 (AA: extra 36-210)-hIgGFc transfected HEK293 (2) cell lysate.
Select
PTPRJ / CD148 Mouse anti-Human Monoclonal (6F2E12) Antibody
Human
ELISA, Flo, WB
Unconjugated
0.1 mg/$426
PTPRJ / CD148 Antibody - Western blot analysis using CD148 mAb against HEK293 (1) and CD148 (AA: extra 36-210)-hIgGFc transfected HEK293 (2) cell lysate.
Select
PTPRJ / CD148 Mouse anti-Human Monoclonal (1D2C11) Antibody
Human
ELISA, Flo, WB
Unconjugated
0.1 mg/$426
PTPRJ / CD148 Antibody - Immunohistochemistry of paraffin-embedded human lung cancer at dilution 1:100
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$282; 100 µl/$348
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
PTPRJ / CD148 Antibody - Western blot analysis of lysate from 293, HeLa cells, using PTPRJ Antibody.
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$318; 100 µg/$378
Select
PTPRJ / CD148 Mouse anti-Human Monoclonal (aa1-444) (MEM-CD148/05) Antibody
Human
Flo
Unconjugated
0.1 mg/$292
Select
PTPRJ / CD148 Mouse anti-Human Monoclonal (aa1-444) (PE) (MEM-CD148/05) Antibody
Human
Flo
PE Conjugated
100 Tests/$355
Select
PTPRJ / CD148 Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
50 µl/$275; 100 µl/$312; 200 µl/$350
PTPRJ / CD148 Antibody - Western blot of PTPRJ / CD148 antibody.
Select
PTPRJ / CD148 Rabbit anti-Mouse Polyclonal (aa567-842) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$297; 200 µl/$338; 500 µl/$475; 1 ml/$543
Select
PTPRJ / CD148 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µl/$275; 100 µl/$312; 200 µl/$350
Select
PTPRJ / CD148 Mouse anti-Human Monoclonal (Biotin) (MEM-CD148/05) Antibody
Human
Flo
Biotin Conjugated
0.1 mg/$327
Viewing 1-25 of 67 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).