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PTPN11 / SHP-2 / NS1
protein tyrosine phosphatase, non-receptor type 11
PTPN11 / SHP-2 / NS1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | protein tyrosine phosphatase, non-receptor type 11 |
| Family/Subfamily: | Protein Phosphatase , NT2 |
| Synonyms: | PTPN11, Bptp-3, BPTP3, CFC, Csw, Corkscrew csw, Gene corkscrew, Phosphatase corkscrew, PTP-2C, SHP2, PTP-1D, PTP2C, SHP-2, SHPTP2, Noonan syndrome 1, SH-PTP2, SH-PTP3 |
| Target Sequences: | NM_002834 NP_002825.3 Q06124 |
Publications (2)
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