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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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PTP1B

protein tyrosine phosphatase, non-receptor type 1

PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: protein tyrosine phosphatase, non-receptor type 1
Family/Subfamily: Protein Phosphatase , NT1
Synonyms: PTPN1, PTP1B, PTP-1B, PTPase 1B
Target Sequences: NM_002827 NP_002818.1 P18031

Publications (1)

1
Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors. Wojtowicz EE, Lechman ER, Hermans KG, Schoof EM, Wienholds E, Isserlin R, van Veelen PA, Broekhuis MJ, Janssen GM, Trotman-Grant A, Dobson SM, Krivdova G, Elzinga J, Kennedy J, Gan OI, Sinha A, Ignatchenko V, Kislinger T, Dethmers-Ausema B, Weersing E, Alemdehy MF, de Looper HW, Bader GD, Ritsema M, Erkeland SJ, Bystrykh LV, Dick JE, de Haan G. Cell stem cell. 2016 September;19:383-96. (Human) [Full Text Article] [PubMed:27424784] [PMC:PMC5500905] Related Antibodies: LS-C61924.

Viewing 1-15 of 15 items
PTP1B Protein
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E. coli
None
Biologically active
100µg   1mg/ml   $275.00; 0.5mg   1mg/ml   $485.00
PTP1B Protein - Purified recombinant protein PTPN1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc + DDK
49.8 kDa
20µg   $890.00
PTP1B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc + DDK
49.8 kDa
20µg   $195.00
Select
E. coli
GST,N-terminus
44 kDa
200µg   $315.00
Select
E. coli
GST,N-terminus
39 kDa
200µg   $315.00
Select
HEK 293 Cells
6His,N-terminus
25 kDa
200µl   $235.00
Select
HEK 293 Cells
6His,N-terminus
25 kDa
100µg   $245.00
PTP1B Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST,N-terminus
10µg   $425.00; 25µg   $590.00
PTP1B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc + DDK
49.8 kDa
100µg   $365.00
PTP1B Protein
Select
Sf9 Cells
DDK,C-terminus
49.8 kDa
20µg   $485.00
PTP1B Protein
Select
E. coli
His, N-Terminal
39.2 KDa
100µg   $485.00
PTP1B Protein - 12.5% SDS-PAGE of human PTPN1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
76.4 kDa
10µg   $425.00; 25µg   $590.00
Select
E. coli
His
38 kDa
50µg   $650.00; 100µg   $980.00
Select
E. coli
None
Biologically active
37.3 kDa
100µg   $395.00
Select
E. coli
None
Biologically active
10µg   $195.00; 50µg   $255.00; 1mg   $1,890.00

Viewing 1-15 of 15 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).