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PTHLH / PTHRP

parathyroid hormone-like hormone

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.

Gene Name: parathyroid hormone-like hormone
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: PTHLH, Osteostatin, PTHR, PTH-related protein, PTHRP, BDE2, HHM, PLP, PTH-rP
Target Sequences: NM_002820 NP_002811.1 P12272

Publications (6)

1
Bone adaptation in response to treadmill exercise in young and adult mice. Gardinier JD, Rostami N, Juliano L, Zhang C. Bone reports. 2018 January;8:29-37. [Full Text Article] [PubMed:29379848] [PMC:PMC5787623] Related Antibodies: LS-B6787.
2
The tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting. Sawsan Elattar, Manali Dimri, Ande Satyanarayana. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2018 September;32:4727-4743. [Full Text Article] [PubMed:29570397] [PMC:PMC6266632]
3
Expression of Signaling Molecules Involved in Embryonic Development of the Insertion Site Is Inadequate for Reformation of the Native Enthesis: Evaluation in a Novel Murine ACL Reconstruction Model. Xiang-Hua Deng, Amir Lebaschi, Christopher L Camp, Camila B Carballo, Nathan W Coleman, Jianchun Zong, Brian M Grawe, Scott A Rodeo. The Journal of bone and joint surgery. American volume. 2018 August;100:e102. [Full Text Article] [PubMed:30063598] [PMC:PMC6661256]
4
Physiologic and molecular characterization of a novel murine model of metastatic head and neck cancer cachexia. Brennan Olson , Mason A Norgard, Peter R Levasseur, Xinxia Zhu, Daniel L Marks. Journal of cachexia, sarcopenia and muscle. 2021 Oct;;12:1312-1332. [Full Text Article] [PubMed:34231343] [PMC:PMC8517353]
5
Parathyroid Hormone-Related Protein Inhibition Blocks Triple-Negative Breast Cancer Expansion in Bone Through Epithelial to Mesenchymal Transition Reversal. Jiarong Li, Anne Camirand, Mahvash Zakikhani, Karine Sellin, Yubo Guo, XiaoRui Luan, Catalin Mihalcioiu, Richard Kremer. JBMR plus. 2022 June;6:e10587. [Full Text Article] [PubMed:35720668] [PMC:PMC9189913] Related Antibodies: LS-C408680.
6
Whole-body and adipose tissue metabolic phenotype in cancer patients. Lindsey J Anderson, Jonathan Lee, Barbara Anderson, Benjamin Lee, Dorota Migula, Adam Sauer, Nicole Chong, Haiming Liu, Peter C Wu, Atreya Dash, Yi-Ping Li, Jose M Garcia. Journal of cachexia, sarcopenia and muscle. 2022 April;13:1124-1133. [Full Text Article] [PubMed:35088949] [PMC:PMC8977952]
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☰ Filters
Products
Proteins (24)
Over-Expression Lysate (10)
Recombinant (14)
PTHLH / PTHRP (24)
No (24)
GST (1)
His (2)
His, N-Terminal (2)
His, N-terminus (1)
His-S (4)
Myc-DDK (Flag) (12)
Bovine (1)
Chicken (1)
Dog (1)
Human (13)
Mouse (2)
Rat (1)
293T Cells (5)
E. coli (11)
HEK 293 Cells (7)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (3)
Biologically active (1)
PTHLH / PTHRP Protein
Select
E. coli
His, N-Terminal
17.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
PTHLH / PTHRP Protein
Select
E. coli
His
19.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
PTHLH / PTHRP Protein - 12.5% SDS-PAGE of human PTHLH stained with Coomassie Blue
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Wheat Germ Extract
GST
44.99 kDa
2 µg/$439
PTHLH / PTHRP Protein - Purified recombinant protein PTHLH was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
15.7 kDa
20 µg/$1,107
PTHLH / PTHRP Protein - Purified recombinant protein PTHLH was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
16 kDa
20 µg/$1,107
Select
E. coli
None
Less than 0.1 ng/µg of protein (less than 1EU/µg).
9.8 kDa
10 µg/$268; 50 µg/$349
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
20 µg/$310; 100 µg/$466; 1 mg/$1,891
Select
E. coli
150 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
16.61 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
PTHLH / PTHRP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
19.9 kDa
100 µg/$494
PTHLH / PTHRP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
16 kDa
100 µg/$494
PTHLH / PTHRP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
16 kDa
100 µg/$494
PTHLH / PTHRP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
15.7 kDa
100 µg/$494
PTHLH / PTHRP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
16 kDa
100 µg/$494
PTHLH / PTHRP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
19.9 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
16 kDa
20 µg/$150
PTHLH / PTHRP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
15.7 kDa
20 µg/$150
PTHLH / PTHRP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
16 kDa
20 µg/$150
PTHLH / PTHRP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
16 kDa
20 µg/$150
PTHLH / PTHRP Protein - Active Parathyroid Hormone Related Protein (PTHrP) by WB
Select
E. coli
His, N-Terminal
18/19kDa
10 µg/$331; 50 µg/$752; 200 µg/$1,365; 100 µg/$1,156; 1 mg/$2,648; 500 µg/$2,144; 5 mg/$5,251; 2 mg/$2,838
PTHLH / PTHRP Protein - Recombinant Parathyroid Hormone Related Protein By SDS-PAGE
Select
E. coli
His-S
21.8 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
PTHLH / PTHRP Protein - Recombinant Parathyroid Hormone Related Protein By SDS-PAGE
Select
E. coli
His-S
21.9 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
PTHLH / PTHRP Protein - Recombinant Parathyroid Hormone Related Protein By SDS-PAGE
Select
E. coli
His-S
21.5 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
PTHLH / PTHRP Protein - Recombinant Parathyroid Hormone Related Protein By SDS-PAGE
Select
E. coli
His-S
21.7 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
Select
E. coli
His, N-terminus
21.7 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).