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Phosphatidylserine (PS) accounts for 5 to 10% of cell membrane phospholipids. In addition to its role as a structural component, PS is involved in cell signaling, blood coagulation, and apoptosis. PS is synthesized by a calcium-dependent base-exchange reaction catalyzed by PS synthases (EC 2.7.8.8), like PTDSS2, that exchange L-serine for the polar head group of phosphatidylcholine (PC) or phosphatidylethanolamine (PE) (Sturbois-Balcerzak et al., 2001 [PubMed 11084049]).
Gene Name: | phosphatidylserine synthase 2 |
Synonyms: | PTDSS2, PSS-2, Phosphatidylserine synthase 2, PSS2, PtdSer synthase 2, Serine-exchange enzyme II |
Target Sequences: | NM_030783 NP_110410.1 Q9BVG9 |
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