PTBP1

polypyrimidine tract binding protein 1

PTBP1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

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Products

Proteins (12)

Type

Over-Expression Lysate (6)

Recombinant (6)

Target

PTBP1 (12)

Publications

No (12)

Tag

GST (2)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (8)

Species

Human (9)

Source

293T Cells (3)

E. coli (1)

HEK 293 Cells (5)

Wheat Germ Extract (3)

Purification

Purified (2)

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Human PTBP1 Protein (Recombinant His, N-Terminal) (aa1-531) - LS-G25069

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

60.9 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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PTBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109094

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.9 kDa

Price:

100 µg/$494

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PTBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109096

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57 kDa

Price:

100 µg/$494

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PTBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117745

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.5 kDa

Price:

100 µg/$494

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Human PTBP1 Protein (Recombinant GST) (Full Length) - LS-G30009

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

86 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PTBP1 Protein (Recombinant GST) (Full Length) - LS-G30008

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

87.01 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PTBP1 Protein (Recombinant GST, N-terminus) (aa45-144) - LS-G59801

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PTBP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66626

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.9 kDa

Price:

20 µg/$1,107

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Human PTBP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66627

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.5 kDa

Price:

20 µg/$1,107

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Human PTBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78136

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57 kDa

Price:

20 µg/$150

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Human PTBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78134

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.5 kDa

Price:

20 µg/$150

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Human PTBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78135

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.9 kDa

Price:

20 µg/$150

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