PSMD10 / Gankyrin

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.

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Products

Proteins (15)

Type

Over-Expression Lysate (4)

Recombinant (11)

Target

PSMD10 / Gankyrin (15)

Publications

No (14)

Yes (1)

Tag

6His, N-terminus (1)

GST (2)

GST, N-terminus (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (6)

Species

Human (13)

Source

293T Cells (2)

E. coli (6)

HEK 293 Cells (4)

Wheat Germ Extract (3)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human PSMD10 / Gankyrin Protein (Recombinant GST) (Full Length) - LS-G30001

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

50.8 kDa

Price:

10 µg/$479; 25 µg/$670

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PSMD10 / Gankyrin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105599

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16 kDa

Price:

100 µg/$494

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Human PSMD10 / Gankyrin Protein (Recombinant) (Met1-Gly226) - LS-G38698

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

24.43kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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PSMD10 / Gankyrin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117749

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.2 kDa

Price:

100 µg/$494

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Human PSMD10 / Gankyrin Protein (Recombinant) - LS-G3418

Source:

E. coli

Tag:

None

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human PSMD10 / Gankyrin Protein (Recombinant His-T7) (aa1-226) - LS-G16294

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.2 kDa

Price:

10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142

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Human PSMD10 / Gankyrin Protein (Recombinant His-SUMO) (Full Length) - LS-G21091

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

40.41 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human PSMD10 / Gankyrin Protein (Recombinant GST, N-terminus) (aa127-226) - LS-G59796

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PSMD10 / Gankyrin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86445

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.2 kDa

Price:

20 µg/$150

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Human PSMD10 / Gankyrin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86447

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16 kDa

Price:

20 µg/$150

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Human PSMD10 / Gankyrin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70174

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16 kDa

Price:

20 µg/$1,107

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Human PSMD10 / Gankyrin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70173

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.2 kDa

Price:

20 µg/$1,107

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Human PSMD10 / Gankyrin Protein (Recombinant 6His, N-terminus) (Glu20-Gly226) - LS-G26465

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

26.6 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949

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Human PSMD10 / Gankyrin Protein (Recombinant) (Met1-Gly226) - LS-G139591

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

24.4 kDa

Price:

10 µg/$376; 50 µg/$526

Select

Human PSMD10 / Gankyrin Protein (Recombinant GST) (Full Length) - LS-G30000

(4.0) Rating

(1) Publication(s)

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

50.6 kDa

Price:

10 µg/$479; 25 µg/$670

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