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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.
Gene Name: | proteasome (prosome, macropain) subunit, beta type, 4 |
Family/Subfamily: | Protease Non Catalytic , Threonine T1 |
Synonyms: | PSMB4, 26 kDa prosomal protein, HsN3, HsBPROS26, Proteasome beta chain, Proteasome chain 3, Proteasome subunit beta type-4, Proteasome beta chain 4, Proteasome subunit HsN3, PROS-26, HN3, Macropain beta chain, PROS26 |
Target Sequences: | NM_002796 NP_002787.2 P28070 |
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