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PSMB11 / BETA5T

Proteasome (prosome, macropain) subunit, beta type, 11

Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).

Gene Name: Proteasome (prosome, macropain) subunit, beta type, 11
Synonyms: PSMB11, BETA5T, Proteasome subunit beta 5T, Proteasome subunit beta-5t
Target Sequences: A5LHX3 A5LHX3

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PSMB11 / BETA5T (2)
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PSMB11 / BETA5T Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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32.3 kDa
100 µg/$494
PSMB11 / BETA5T Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).