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Properdin / CFP

complement factor properdin

Properdin / CFP is a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene Name: complement factor properdin
Synonyms: CFP, Complement factor P, Complement factor properdin, PFC, PFD, Properidin, BFD, Properdin, Properdin P factor, complement
Target Sequences: NM_002621 NP_002612.1 P27918

Publications (1)

1
Effects of immunoadsorption combined with membrane filtration on complement markers - results of a randomized, controlled, crossover study. Federica Defendi, Paolo Malvezzi, Farsad Eskandary, Jean-Yves Cesbron, Lionel Rostaing, Georg A Böhmig, Chantal Dumestre-Pérard. Transplant international : official journal of the European Society for Organ Transplantation. 2019 August;32:876-883. [Full Text Article] [PubMed:30901502] Related Antibodies: LS-C195843.

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Products
Proteins (14)
Over-Expression Lysate (4)
Recombinant (10)
Properdin / CFP (14)
No (14)
6His, N-terminus (2)
6His-Myc, C-terminus (1)
GST (1)
GST, N-terminus (1)
His (3)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (4)
Human (7)
Mouse (5)
293T Cells (2)
E. coli (6)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Yeast (2)
Purified (5)
Properdin / CFP Protein - Recombinant Complement Factor P By SDS-PAGE
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E. coli
His, N-Terminal
18.4 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
Properdin / CFP Protein - Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of Recombinant Mouse Properdin(Cfp) could indicate that this peptide derived from Yeast-expressed Mus musculus (Mouse) Cfp.
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Yeast
6His-Myc, C-terminus
50.9 kDa
100 µg/$570; 20 µg/$395; 1 mg/$1,973
Properdin / CFP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
51.28 kDa
100 µg/$494
Properdin / CFP Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Properdin / CFP Protein - 12.5% SDS-PAGE of human CFP stained with Coomassie Blue
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Wheat Germ Extract
GST
77.33 kDa
2 µg/$439
Properdin / CFP Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Properdin / CFP Protein - Recombinant Complement Factor P By SDS-PAGE
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E. coli
His-T7
17.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
Properdin / CFP Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
Properdin / CFP Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Properdin / CFP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
51.28 kDa
20 µg/$150
Properdin / CFP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
51.28 kDa
20 µg/$150
Properdin / CFP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
51.28 kDa
100 µg/$494
Select
E. coli
His
19.1 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
Select
E. coli
His
19.3 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).